Loss of decay-accelerating factor triggers podocyte injury and glomerulosclerosis
نویسندگان
چکیده
منابع مشابه
Podocyte injury and glomerulosclerosis in hyperhomocysteinemic rats.
BACKGROUND/AIMS We previously reported that increase in plasma homocysteine (Hcys) levels by a 6-week methionine treatment produced remarkable glomerular injury. However, the mechanism by which hyperhomocysteinemia (hHcys) produces glomerular injury remains unknown. The present study was to observe when glomerular injury happens during hHcys and to explore the possible role of podocyte injury i...
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Focal segmental glomerulosclerosis (FSGS) is a common cause of proteinuria and nephrotic syndrome leading to end stage renal disease (ESRD). There are two types of FSGS, primary (idiopathic) and secondary forms. Secondary FSGS shows less severe clinical features compared to those of the primary one. However, secondary FSGS has an important clinical significance because a variety of renal diseas...
متن کاملFocal and segmental glomerulosclerosis induced in mice lacking decay-accelerating factor in T cells.
Heritable and acquired diseases of podocytes can result in focal and segmental glomerulosclerosis (FSGS). We modeled FSGS by passively transferring mouse podocyte-specific sheep Abs into BALB/c mice. BALB/c mice deficient in the key complement regulator, decay-accelerating factor (DAF), but not WT or CD59-deficient BALB/c mice developed histological and ultrastructural features of FSGS, marked ...
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In our study [4], FGF2 and FGF2-neutralizing antibody were administered to animals with PAN nephropathy. After PAN injection, recombinant FGF2 Introduction (group F), FGF2-neutralizing antibody (group M) or the same volume of physiological saline (group C) was Recent studies point to an important role for podocytes injected for 4 days via the tail vein, and the animals in the physiology and pat...
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ژورنال
عنوان ژورنال: Journal of Experimental Medicine
سال: 2020
ISSN: 0022-1007,1540-9538
DOI: 10.1084/jem.20191699